diff --git a/Lib/test/test_dtrace.py b/Lib/test/test_dtrace.py
index 3de87fc704d43e..f0ce12d1eaa447 100644
--- a/Lib/test/test_dtrace.py
+++ b/Lib/test/test_dtrace.py
@@ -324,6 +324,10 @@ class TraceTests:
 
     @classmethod
     def setUpClass(self):
+        if not sysconfig.get_config_var('WITH_DTRACE'):
+            raise unittest.SkipTest(
+                "CPython must be configured with the --with-dtrace option."
+            )
         self.backend.assert_usable()
 
     def run_case(self, name):