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bmadero/README.md

Bryan Madero

Postdoctoral Research Scholar · Mallinckrodt Institute of Radiology · Washington University School of Medicine
NIH T32 Trainee (TIRS Program) · Started July 2026


I study white matter integrity and cerebral biomarkers of brain aging using PET and MRI. My core postdoc project frames dynamic [¹¹C]PiB PET as a marker of white matter integrity and amyloid burden.

My PhD dissertation examined the morphology of the posterior middle frontal sulci (pmfs), a cortical landmark that varies substantially across individuals, and its relationship to executive function and resting-state network topology in older adults. That work drew on the EXTEND dataset and combined structural MRI, resting-state fMRI, group ICA, dual regression, and custom connectivity fingerprinting methods.


Research Interests

  • White matter integrity and cerebrovascular contributions to brain aging
  • PET/MRI biomarkers of aging and neurodegeneration
  • Cortical morphology and individual differences in cognition
  • Large-scale functional network organization in aging
  • Executive function and cognitive control

Tools & Methods

fMRIPrep XCP-D FSL / MELODIC Dual Regression R / lme4 Python FreeSurfer


Selected Work

Global functional connectivity of cognitive control networks predicts task-switching performance in older adults
B. Madero, M. Sodoma, C. Oehler, V. A. Magnotta, J. D. Long, E. Hazeltine, M. W. Voss
Cortex · 2026 · doi: 10.1016/j.cortex.2026.01.002


Projects

Project Description Status
bmadero.github.io Personal academic portfolio Live
Studio Scheduler Constraint-based scheduling app for competitive dance studios In development
BiblioMate Research library organizer with D3 visualizations and local LLM pipeline Active

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