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null-distribution

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A statistical framework for detecting significant drug combination synergies in cancer. By leveraging tissue-specific reference null distributions across multiple synergy metrics, we compute empirical p-values to standardize synergy detection, uncover novel interactions, and enable rigorous evaluation of drug combinations.

  • Updated Mar 18, 2026
  • R

Code to reproduce the null-distribution modeling, significance-level estimation, and null-normalized tracking score (NNTS) results from Geirnaert et al., "Modeling and Interpreting Correlations, Null Distributions and Significance Levels in Neural Tracking of Natural Stimuli."

  • Updated Aug 6, 2026
  • MATLAB

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